Instructors
Dave Lewis
Credentials: PhD in Biochemistry
Position title: Head of Therapeutic Development
Empirico, Inc.
Thomas Machleidt
Credentials: PhD in Cellular and Molecular Biology
Position title: Director of Research
Promega Corporation
Delinda Johnson
Credentials: PhD in Biochemistry
Position title: Senior Scientist
UW-Madison School of Pharmacy
Course Overview
crb830: Early Drug Discovery
Year 2, Fall Semester (4 credits)
This in-depth course explores the complex process of drug discovery.
Classroom and lab sessions will give you a comprehensive look at early stage discovery—from disease mechanisms and target identification through formulation delivery and safety pharmacology.
You’ll receive in-depth scientific information from faculty and special presenters from biotech firms, pharmaceutical companies and academic institutions.
At the end of the course, you’ll understand the processes, technologies, scientific principles and major challenges of the early drug discovery process as it continues to evolve.
Here are some of the topics taught in this course:
Session Topics from Fall 2021
Session 1: Introduction to Drug Discovery and Target Identification
Session 2: Target Identification and Validation
Session 3: Assays in Drug Discovery
Session 4: Lead Identification and Drug Design, Optimization and Medicinal Chemistry; Vaccines
Session 5: Next Generation Sequencing, Antibodies and Diversity, and Drug Delivery
Session 6: Drug Formulation; Preclinical Studies for Toxicology and Immunogenicity; Ethical Issues in Personalized Medicine
Session 7: Drug Discovery Case Studies; Final Course Discussion